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Department of Dermatology, the Second Hospital of Zhejiang University

Man  Lab

Prof. Dr. Xiao-Yong Man

PhD, MD

Director

Department of Dermatology

Second Affiliated Hospital, Zhejiang University School of Medicine

88 Jiefang Rd

310009, Hangzhou, Zhejiang,China

E-mail: manxy@zju.edu.cn

Xiao-Yong Man is the associate professor of medicine at Zhejiang University; Director of the Department of Dermatology and Venereology, Second Affiliated Hospital, Zhejiang University School of Medicine; Board member of Committee of Chinese Society of Dermatology (CSD), Chinese Medicine Association (CMA). He is the vice-chairman of Chinese Association of Rehabilitation Dermatology(CARD), Committee of Dermatology of Chinese Research Hospital Association .He advocated the establishment of the Chinese Psoriasis Real World Evidence Research Group Chinese(CPRWERG).

Zheng  Lab

Prof. Dr. Min Zheng

PhD, MD

Honorary Director

Department of Dermatology

Second Affiliated Hospital, Zhejiang University School of Medicine

88 Jiefang Rd

310009, Hangzhou, Zhejiang,China

E-mail: minz@zju.edu.cn

Min Zheng is the professor of medicine at Zhejiang University; Honorary director of the Department of Dermatology and Venereology, Second Affiliated Hospital, Zhejiang University School of Medicine; Honorary President of Asian Society for Psoriasis and member of International Psoriasis Council. He is a member of the Scientific Committee of Skin and Psoriasis Inflammation Network and liaison officer in China.

Yuan Zhou

Distinguished Research Fellow

Dermatologist

Second Affiliated Hospital, 

School of Medicine, Zhejiang University

E-mail: yuanz@zju.edu.cn

Zhaoyuan Wang

Ph.D. 

Dermatologist Second Affiliated Hospital, 

School of Medicine, Zhejiang University 

E-mail:daisy_wzy@zju.edu.cn

Siqi Chen

Ph.D. 

Dermatologist Second Affiliated Hospital,

School of Medicine, Zhejiang University 

E-mail:564750757@qq.com

Binxi Yan

M.D. 

Dermatologist Second Affiliated Hospital, 

School of Medicine, Zhejiang University 

E-mail:daisy_wzy@zju.edu.cn

Xueyan Chen

Ph.D. 

Dermatologist Second Affiliated Hospital, 

School of Medicine, Zhejiang University 

E-mail:564750757@qq.com

Fan Xu

Ph.D. 

Candidate Second Affiliated Hospital, School of Medicine, Zhejiang University 

E-mail: fanxu_2018@163.com

Yingzhe Cui

M.D. 

Candidate Second Affiliated Hospital,

 School of Medicine, Zhejiang University 

E-mail: cuiyingzhe90@zju.edu.cn

Yuxin Zheng

Ph.D. 

candidate Second Affiliated Hospital, School of Medicine, Zhejiang University E-mail: zhengyuxin@zju.edu.cn

Xibei Chen

M.D. 

candidate Second Affiliated Hospital, 

School of Medicine, Zhejiang University 

E-mail: chenxb@zju.edu.cn

Nichang Fu

M.D. 

Candidate Second Affiliated Hospital, 

School of Medicine, Zhejiang University 

E-mail: nichang1998@zju.edu.cn

Xingyu Yang

M.D. 

Candidate Second Affiliated Hospital, 

School of Medicine, Zhejiang University 

E-mail: zjuyxy@zju.edu.cn

Liran Ye

M.D. 

Candidate Second Affiliated Hospital, 

School of Medicine, Zhejiang University 

E-mail: liranye@zju.edu.cn

Jie Yu

M.D. 

Candidate Second Affiliated Hospital, 

School of Medicine, Zhejiang University 

E-mail:yujie221@zju.edu.cn

Yingying Li

Graduate Student Second Affiliated Hospital, 

School of Medicine, Zhejiang University 

E-mail:lyyupup99@zju.edu.cn

The Man/Zheng lab takes focus on inflammatory skin diseases, especially the pathogenesis of psoriasis. The lab Relies on the Zhejiang Provincial Key Laboratory of Medical Molecular Biology and the Cancer Institute of the Second Hospital of Zhejiang University, which can fully carry out molecular biology, immunology, cell biology, genetic engineering, and other aspects of research. In recent years, we have undertaken three major projects of the National Natural Science Foundation of China, more than 20 general and youth projects, and two scientific research projects of the Sino-German Science Center, etc. We have published more than 200 academic papers in internationally renowned journals such as JAMA, NEIM, BDMD, etc., and have also had several cooperative research in the University of California, Cornell University, Mnster University, Keele University, Fukui University, and Lausanne University.

Recent Publications:

1. Zhou, Y., Xu, F., Chen, X.Y., Yan, B.X., Wang, Z.Y., Chen, S.Q., Zheng, M., and Man, X.Y. (2022). The epidermal immune microenvironment plays a dominant role in psoriasis development, as revealed by mass cytometry. Cell Mol Immunol 19, 1400-1413. 10.1038/s41423-022-00940-8.

2. Chen, S.Q., Chen, X.Y., Cui, Y.Z., Yan, B.X., Zhou, Y., Wang, Z.Y., Xu, F., Huang, Y.Z., Zheng, Y.X., and Man, X.Y. (2022a). Cutaneous nerve fibers participate in the progression of psoriasis by linking epidermal keratinocytes and immunocytes. Cell Mol Life Sci 79, 267. 10.1007/s00018-022-04299-x.


3. Chen, X.Y., Xu, F., Chen, J.Q., Landeck, L., Chen, S.Q., Zhou, Y., Wang, Z., Fu, N.C., Zheng, M., Zhang, X., and Man, X.Y. (2022b). UBE2L3 Reduces TRIM21 Expression and IL-1beta Secretion in Epidermal Keratinocytes and Improves Psoriasis-Like Skin. J Invest Dermatol. 10.1016/j.jid.2022.10.016.


4. Huang, Y.Z., Zheng, Y.X., Zhou, Y., Xu, F., Cui, Y.Z., Chen, X.Y., Wang, Z.Y., Yan, B.X., Zheng, M., and Man, X.Y. (2022). OAS1, OAS2, and OAS3 Contribute to Epidermal Keratinocyte Proliferation by Regulating Cell Cycle and Augmenting IFN-1Induced Jak1Signal Transducer and Activator of Transcription 1 Phosphorylation in Psoriasis. J Invest Dermatol 142, 2635-2645 e2639. 10.1016/j.jid.2022.02.018.


5. Ye, L.R., Yan, B.X., Chen, X.Y., Chen, S.Q., Chen, J.Q., Man, X.Y., and Chinese Psoriasis Real World Evidence Research, G. (2022). Extended dosing intervals of ixekizumab for psoriasis: A single-center, uncontrolled, prospective study. J Am Acad Dermatol 86, 1348-1350. 10.1016/j.jaad.2021.04.093.




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